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How Cholesterol is Made in Your Body

📑 10 slides 👁 35 views 📅 1/23/2026
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Introduction to Cholesterol

Cholesterol is a waxy substance essential for building cells and hormones.

Introduction to Cholesterol
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Sources of Cholesterol

  • Dietary cholesterol comes from animal products like meat, eggs, and dairy.
  • Plant-based foods contain no cholesterol but may affect its absorption.
  • The body regulates cholesterol production based on dietary intake.
Sources of Cholesterol
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Liver's Role in Cholesterol

  • The liver synthesizes cholesterol from acetyl-CoA molecules.
  • It produces about 1,000 mg of cholesterol daily to meet bodily needs.
  • The liver also removes excess cholesterol from the bloodstream.
Liver's Role in Cholesterol
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Cholesterol Transport

  • Lipoproteins carry cholesterol through the bloodstream.
  • LDL (low-density lipoprotein) is 'bad' cholesterol that can clog arteries.
  • HDL (high-density lipoprotein) is 'good' cholesterol that removes excess.
Cholesterol Transport
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Cholesterol and Cell Membranes

  • Cholesterol stabilizes cell membranes and maintains their fluidity.
  • It accounts for about 30% of animal cell membrane lipids.
  • Without cholesterol, cells would be too rigid or too permeable.
Cholesterol and Cell Membranes
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Cholesterol in Hormone Production

  • Cholesterol is the precursor for steroid hormones like estrogen and testosterone.
  • The adrenal glands use cholesterol to produce cortisol and aldosterone.
  • Vitamin D synthesis also begins with cholesterol in the skin.
Cholesterol in Hormone Production
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Regulation of Cholesterol

  • The body maintains cholesterol balance through feedback mechanisms.
  • When dietary cholesterol is high, the liver reduces its own production.
  • Statins work by inhibiting an enzyme in cholesterol synthesis.
Regulation of Cholesterol
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Cholesterol and Heart Health

  • Excess LDL cholesterol can form plaques in artery walls.
  • These plaques narrow arteries and increase heart attack risk.
  • Optimal total cholesterol should be under 200 mg/dL.
Cholesterol and Heart Health
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Managing Cholesterol Levels

  • Exercise increases HDL while reducing LDL and triglycerides.
  • Soluble fiber helps remove cholesterol through digestion.
  • Replacing saturated with unsaturated fats improves cholesterol profile.
Managing Cholesterol Levels
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Summary and Key Takeaways

  • Cholesterol is essential but must be balanced for good health.
  • The liver produces most cholesterol, influenced by diet and genetics.
  • Regular check-ups and lifestyle changes can maintain healthy levels.
Summary and Key Takeaways
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